Benzoisothiazole-and benzisoxazole-3-carboxamides

ABSTRACT

The present invention relates to benzisothiazole- and benzisoxazole-3-carboxamides of the formula I &lt;CHEM&gt; wherein R&lt;1&gt; is hydrogen or loweralkyl; R&lt;2&gt; is loweralkyl, or a group of the formula &lt;CHEM&gt; R&lt;3&gt; is hydrogen or loweralkyl; A is loweralkylene, a group of the formula -CHR&lt;4&gt;CH=CHCHR&lt;4&gt;-, or -CHR&lt;4&gt;C IDENTICAL CHR&lt;4&gt;-; R&lt;4&gt; is hydrogen or loweralkyl; X is O or S; W is N or CH; Y is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, or trifluoromethyl; Z is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, or trifluoromethyl; n is 1 or 2; wherein the solid line (-) refers to the point of attachment of the group to the indicated member of the formula; the geometric and optical isomers thereof; or a pharmaceutically acceptable salt thereof, useful for the treatment of psychoses, alone or in combination with inert adjuvants.



